Mark Zabel is a professor specializing in Prion Biology and Immunology. His research delves into the intricate interactions between prions, which are infectious proteins, and the immune system. Specifically, he focuses on understanding how prions enter cells, move around and cause disease. Much remains unknown about the specific molecules on cell surfaces that govern these processes. To tackle this mystery, Zabel’s laboratory utilizes genetically modified mice that carry genes for prion proteins found in deer or sheep, combined with genes for certain components of the innate immune system. By studying where prions first appear in the body and experimenting with therapeutic approaches involving RNA molecules, his team aims to develop strategies for combating prion infections.

Zabel earned his B.A. at Loyola University of Chicago, his M.S. at Southern Illinois University and his Ph.D. at University of Utah.